Quote of the Month

"If a man has learnt to know a thing in itself, and in its relation to surrounding phenomena, he has got from a University what it is its proper duty to teach." - Thomas Carlyle (1866).

Introduction


Welcome to the Eckert Lab located in the Department of Biology at Virginia Commonwealth University. We are a plant evolutionary genomics lab. Research topics range from the dissection of adaptive plant phenotypes into their genetic components to inferences of genome-wide patterns of polymorphism, divergence and natural selection. Current focal points of research are:

Genetic Architecture of Adaptation

How do woody plants adapt to their environments? What are the genes that facilitate this process? How are these genes organized within the genomes of woody plants? We try to answer these questions using a variety of approaches ranging from population genetic surveys of natural populations to association genetic dissection of complex phenotypes. The unifying theme underlying all of these approaches is the discovery of the genetic basis of adaptive plant phenotypes.

Statistical Methods and Adaptation

Standing patterns of genetic diversity result from the interplay of several population genetic processes, such as natural selection, genetic drift and migration. When methods developed to identify these processes are used in a hypothesis testing framework, however, they do not often exhaustively divide the sample space into mutually incompatible outcomes; so that rejection of one hypothesis, a null hypothesis for example, does not necessarily imply that the alternative is true or even likely. The reason is that several different processes can individually, as well as jointly, result in the same patterns. It is prudent, therefore, to utilize a range of methods that each examines different aspects of the standing patterns of genetic diversity. Recently we have begun collaborating with Rodney Dyer and his lab to examine the use of his measure of conditional genetic covariance, in combination with high-throughput SNP genotyping data, to infer patterns of natural selection across genomes.

Phylogeography and Adaptation

The woody plant flora of North America is composed of a fascinating diversity of species. We use a variety of phylogeographic, biogeographic and phylogenetic approaches with which to understand the origin and diversification of species comprising this flora. Our approaches tend to be hypothesis driven where multiple competing hypotheses are proposed and the best one(s) is/are chosen using some form of statistical model selection. This is also important because divergence history confounds the ability to identify adaptive genetic variants.

Below you will find news and events. Links to specific lab personnel are listed on the left. You can find personal webpages by clicking on the picture of the person.

News in the Lab

There is always something exciting happening in the Eckert lab.

05-Apr-2017: Brandon Lind has published his first paper about the polygenic basis of local adaptation across populations of whitebark pine (Pinus albicaulis) located in the Lake Tahoe Basin. Check it out at Molecular Ecology.

01-Apr-2017: Dr. Justin Bagley has started as the newest postdoctoral scholar in the Eckert lab.

27-Nov-2016: Madison Glackin, an undergraduate researcher in the lab, recently was selected to participate in the Panama Avian Field Ecology Study Abroad course at VCU. Congratulations, Madison!

Spring 2014 (01/29/2014)


A single-tree linkage map


The spring semester has finally begun. Members of the lab are off and running on their respective projects. Grants are being applied for and papers are being written. Life could not be better.

Chris has begun his sample collections for his NSF funded postdoctoral fellowship and has already contributed to several projects in the lab. These projects range from production of genotype data from RADseq libraries to analysis of data for linkage map construction to association genetics of dispersal traits for gypsy moths. 
 
Brandon is busily preparing for his qualifying exam and defense of his dissertation proposal. In his spare time he is working on spatial patterns of seedling occurrences at Teakettle.

Ethan is busily adjusting to graduate school, preparing his thesis project, and starting analysis of phenotype data for his thesis about the genetic architecture of water-use efficiency in foxtail pine. 

Erin is doing just about everything, but is working especially hard on getting the RADseq libraries for gypsy moth prepared. This is also Erin's last full semester. She is off to a MD/Ph.D. program at Virginia Tech later in the year. We are all happy for her, but will be lost for awhile.

Quercus-Umbellularia woodlands in the hills of Napa, CA
As for me, I drink coffee in my office and watch all of these hard working young folk put me to shame.

As usual, the Eckert lab is looking for graduate students, especially MS students interested in genomics or ecological genetics. Please contact me if you are interested. Funding for VCU M.S. students is quite reasonable.